Novel Delivery Vehicle for Cell Transfection

The Problem Nanoparticles can be manufactured with tunable size, shape, and surface as well as biological activity. Their role as nanocarriers is well established. While many nanoparticles are stable as an aqueous colloid, ferrofluid, they maintain an insufficient active surface and are limited in their capacity for further modification or surface engineering. The Solution In…

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A Novel Approach for Rational Hepatitis C Virus-Vaccine Design

The Problem HCV is a major public health problem, with over 185 million people infected worldwide and at risk for developing life-threatening liver disease. Although FDA approved several Direct-Acting Antiviral Drugs (DAAs) demonstrating high efficacy and safety, they are highly expensive and unaffordable. Vaccines typically represent the most cost-effective strategy to prevent infectious disease which…

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Effective Nanoscale Targeted Anti-leishmania Drug and Technological Platform for Nano-medicine

The Problem Leishmaniasis is a vector-borne tropical disease that affects 88 countries worldwide. The causal agent is a parasitic protozoon, Leishmania ssp. Cutaneous leishmaniasis (CL), caused by L. major, L. mexicana, and visceral leishmaniasis caused by L. donovani, is one of the most important neglected tropical diseases. Available treatments are highly toxic, and the serious…

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Targeting Amyloid Diseases with Self-assembled Cyclic D, L-α-Peptides

The Problem Protein misfolding and aggregation is the fundamental cause of more than 20 amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. These conditions include Alzheimer’s, Parkinson’s, and Huntington’s diseases, and type II diabetes. For Alzheimer’s disease (AD), the oligomerization of amyloid-beta (Aβ) and tau to soluble oligomers and…

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Novel Personalized Amd and Diabetic Retinopathy Treatment

The Problem Age-Related Macular Degeneration (AMD) and Diabetic Retinopathy (DR) are leading causes of blindness in the Western world. Both are characterized by pathological angiogenesis in the various eye structures. Current treatment for AMD and DR includes monthly intraocular injection of various anti-VEGF agents. Novel biological drug family based on nucleic acid-based ligands, aptamers, is…

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Novel Drug for Glaucoma Treatment

The Problem Glaucoma is one of the leading causes of blindness in the world. It is a slow and progressive disease that can lead to vision loss over a long period of time. Over 60 million people worldwide lives with glaucoma using multiple therapies in order to prevent blindness- and the patients’ number will grow…

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Novel Peptides for Treating Cocaine Addiction And Pain

The Problems Drug addiction is a scourge of both developed and less-developed societies. The economic impact of drug addiction includes direct treatment costs as well as lost productivity and crime. Neuropathic pain is a chronic pain condition caused by a primary lesion or dysfunction in the nervous system. It can be a consequence of many different…

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Surface Engineering & Disaggregation Features of Strong Hardness Chemically Stable Nanodiamonds

The Problem The two major pain points of fully bio-compatible non-toxic carbon-based mechanically hard 4-10 nm-sized nanomaterials (nanodiamonds-NDs) are their high reaction times and their extreme-sized methodologies. These two lead to very difficult surface-functionalizing in a versatile manner for a wide range of full various domains applications. The Solution Our innovation successfully discovered that extremely…

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Prevention and Treatment of Viral Infections with Nano-particles Capped with Functional Groups

The Problem Viral infections continuously take place and pose major public health threats; yet, their prevention and treatment modalities are limited while emerging resistant viruses call for the development of alternative treatments. The Solution We developed a novel approach for the prevention and treatment of infections caused by viruses which attach cells via heparan sulfate binding,…

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Improved Tumor Margins Detection Using Gold Nano-rods

The Problem Most optical-physiological diagnoses are based on the insertion of light, with known parameters, to a tested tissue, followed by the measurement of the reflected, transmitted, or absorbed light. Changes in the optical properties of this light such as its spectrum, polarization, or intensity, compared to the injected light, result from interactions of the…

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