Novel strategy for targeting glycosylated patterns on cancer cells using CAR T‑cells

The Problem Immunotherapy has become a revolution in the area of cancer treatment. Compared to the traditional methods, such as invasive surgeries, radiation, and chemotherapy, immunotherapy is more specific and less toxic to patients. Chimeric antigen receptor (CAR)-engineered T cell therapy is considered a promising approach since it has shown remarkable ability to eliminate tumors…

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ADAR inhibitors to suppress resistance to immune checkpoint inhibitors

The Problem In recent years, targeted immune therapies are emerging as standard treatments for advanced-stage cancers. These drugs target cell surface checkpoint proteins to stimulate the recognition and destruction of cancer cells by the immune system. Nevertheless, while the immune checkpoint blockade approach can induce durable responses across multiple types of malignancies, these remarkable responses…

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A Novel Approach for Rational Hepatitis C Virus-Vaccine Design

The Problem HCV is a major public health problem, with over 185 million people infected worldwide and at risk for developing life-threatening liver disease. Although FDA approved several Direct-Acting Antiviral Drugs (DAAs) demonstrating high efficacy and safety, they are highly expensive and unaffordable. Vaccines typically represent the most cost-effective strategy to prevent infectious disease which…

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Novel Therapeutic Antibodies for Robo Receptors

The Problem De-regulation of Robo receptors appear in a number of diseases and types of cancer and the therapeutic potential for drugs that will modulate Robo activities is therefore high, but no such drugs exist. The Solution Novel structure-based design of agonistic and antagonistic antibodies for Robo receptors. The Commercial Benefit Anti-Robo antibodies can be used…

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Effective Nanoscale Targeted Anti-leishmania Drug and Technological Platform for Nano-medicine

The Problem Leishmaniasis is a vector-borne tropical disease that affects 88 countries worldwide. The causal agent is a parasitic protozoon, Leishmania ssp. Cutaneous leishmaniasis (CL), caused by L. major, L. mexicana, and visceral leishmaniasis caused by L. donovani, is one of the most important neglected tropical diseases. Available treatments are highly toxic, and the serious…

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Targeting Amyloid Diseases with Self-assembled Cyclic D, L-α-Peptides

The Problem Protein misfolding and aggregation is the fundamental cause of more than 20 amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. These conditions include Alzheimer’s, Parkinson’s, and Huntington’s diseases, and type II diabetes. For Alzheimer’s disease (AD), the oligomerization of amyloid-beta (Aβ) and tau to soluble oligomers and…

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Novel Personalized Amd and Diabetic Retinopathy Treatment

The Problem Age-Related Macular Degeneration (AMD) and Diabetic Retinopathy (DR) are leading causes of blindness in the Western world. Both are characterized by pathological angiogenesis in the various eye structures. Current treatment for AMD and DR includes monthly intraocular injection of various anti-VEGF agents. Novel biological drug family based on nucleic acid-based ligands, aptamers, is…

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Novel Drug for Glaucoma Treatment

The Problem Glaucoma is one of the leading causes of blindness in the world. It is a slow and progressive disease that can lead to vision loss over a long period of time. Over 60 million people worldwide lives with glaucoma using multiple therapies in order to prevent blindness- and the patients’ number will grow…

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Novel Peptides for Treating Cocaine Addiction And Pain

The Problems Drug addiction is a scourge of both developed and less-developed societies. The economic impact of drug addiction includes direct treatment costs as well as lost productivity and crime. Neuropathic pain is a chronic pain condition caused by a primary lesion or dysfunction in the nervous system. It can be a consequence of many different…

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