Large Scale Detection and Quantification of Post Translational Protein Modifications
The amount of biological material and reagents available for PTM analysis is usually very limited. This is even more pronounced for membrane proteins. In contrast, the amount required for analysis PTM is significant. This discrepancy makes PTM analysis very difficult.
The minute amounts of biological material and reagents required for analysis using IMPA override the inherent limitation of PTM research imposed by MS, enabling application to low-mass tissues with relevance to basic and translational science