Large Scale Detection and Quantification of Post Translational Protein Modifications

The Problem The amount of biological material and reagents available for PTM analysis is usually very limited. This is even more pronounced for membrane proteins. In contrast, the amount required for analysis PTM is significant. This discrepancy makes PTM analysis very difficult. The Solution The minute amounts of biological material and reagents required for analysis using…

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Advanced Microscopic Methods to Measure Dynamic Patterns of Intracellular and Intranuclear Proteins in Living Mammalian Cells

The Problem The appropriate functioning of living cells depends on a variety of dynamic processes that necessitate delicate motion, transportation, association, and disassociation in time and space. For proteins, it is important to know: Is there a mobile fraction and a fixed (bound) fraction? What is the ratio between these two sub-populations? What is the concentration…

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Novel Delivery Vehicle for Cell Transfection

The Problem Nanoparticles can be manufactured with tunable size, shape, and surface as well as biological activity. Their role as nanocarriers is well established. While many nanoparticles are stable as an aqueous colloid, ferrofluid, they maintain an insufficient active surface and are limited in their capacity for further modification or surface engineering. The Solution In…

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