Posts by Assaf Sagiv
INNOVATIVE MAGNETIC GEL PLATFORM FOR TRANSPLANTATION
A Proposed Solution for Transplantation Using Magnetic Gel Mimicking the nature composition and structure of tissues is a considerable challenge in medicine. Currently this can be partially achieved with prefabricated implants. Prof. Shefi’s team invented a novel approach of injectable biomaterials, to be incorporated directly into the injured site. Advantages: Directly injectable without full operation…
Read MoreLarge Scale Detection and Quantification of Post Translational Protein Modifications
The Problem The amount of biological material and reagents available for PTM analysis is usually very limited. This is even more pronounced for membrane proteins. In contrast, the amount required for analysis PTM is significant. This discrepancy makes PTM analysis very difficult. The Solution The minute amounts of biological material and reagents required for analysis using…
Read MoreNovel Delivery Vehicle for Transfection
What You Need to Know About Cell Transfection Nanoparticles can be manufactured with tunable size, shape, and surface as well as biological activity. Their role as nanocarriers is well established. While many nanoparticles are stable as an aqueous colloid, ferrofluid, they maintain an insufficient active surface and are limited in their capacity for further modification…
Read MoreNovel strategy for targeting glycosylated patterns on cancer cells using CAR-cells
The Problem Immunotherapy has become a revolution in the area of cancer treatment. Compared to the traditional methods, such as invasive surgeries, radiation, and chemotherapy, immunotherapy is more specific and less toxic to patients. Chimeric antigen receptor (CAR)-engineered T cell therapy is considered a promising approach since it has shown remarkable ability to eliminate tumors…
Read MoreADAR inhibitors to suppress resistance to immune checkpoint inhibitors
The Problem In recent years, targeted immune therapies are emerging as standard treatments for advanced-stage cancers. These drugs target cell surface checkpoint proteins to stimulate the recognition and destruction of cancer cells by the immune system. Nevertheless, while the immune checkpoint blockade approach can induce durable responses across multiple types of malignancies, these remarkable responses…
Read MoreA Novel Approach for Rational Hepatitis C Virus-Vaccine Design
The Problem HCV is a major public health problem, with over 185 million people infected worldwide and at risk for developing life-threatening liver disease. Although FDA approved several Direct-Acting Antiviral Drugs (DAAs) demonstrating high efficacy and safety, they are highly expensive and unaffordable. Vaccines typically represent the most cost-effective strategy to prevent infectious disease which…
Read MoreNovel Therapeutic Antibodies for Robo Receptors
The Problem De-regulation of Robo receptors appear in a number of diseases and types of cancer and the therapeutic potential for drugs that will modulate Robo activities is therefore high, but no such drugs exist. The Solution Novel structure-based design of agonistic and antagonistic antibodies for Robo receptors. The Commercial Benefit Anti-Robo antibodies can be used…
Read MoreEffective Nanoscale Targeted Anti-leishmania Drug and Technological Platform for Nano-medicine
The Problem Leishmaniasis is a vector-borne tropical disease that affects 88 countries worldwide. The causal agent is a parasitic protozoon, Leishmania ssp. Cutaneous leishmaniasis (CL), caused by L. major, L. mexicana, and visceral leishmaniasis caused by L. donovani, is one of the most important neglected tropical diseases. Available treatments are highly toxic, and the serious…
Read MoreTargeting Amyloid Diseases with Self-assembled Cyclic D, L-α-Peptides
The Problem Protein misfolding and aggregation is the fundamental cause of more than 20 amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. These conditions include Alzheimer’s, Parkinson’s, and Huntington’s diseases, and type II diabetes. For Alzheimer’s disease (AD), the oligomerization of amyloid-beta (Aβ) and tau to soluble oligomers and…
Read MoreNovel Personalized Amd and Diabetic Retinopathy Treatment
The Problem Age-Related Macular Degeneration (AMD) and Diabetic Retinopathy (DR) are leading causes of blindness in the Western world. Both are characterized by pathological angiogenesis in the various eye structures. Current treatment for AMD and DR includes monthly intraocular injection of various anti-VEGF agents. Novel biological drug family based on nucleic acid-based ligands, aptamers, is…
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