Archive for December 2020
Novel Therapeutic Antibodies for Robo Receptors
The Problem De-regulation of Robo receptors appear in a number of diseases and types of cancer and the therapeutic potential for drugs that will modulate Robo activities is therefore high, but no such drugs exist. The Solution Novel structure-based design of agonistic and antagonistic antibodies for Robo receptors. The Commercial Benefit Anti-Robo antibodies can be used…
Read MoreEffective Nanoscale Targeted Anti-leishmania Drug and Technological Platform for Nano-medicine
The Problem Leishmaniasis is a vector-borne tropical disease that affects 88 countries worldwide. The causal agent is a parasitic protozoon, Leishmania ssp. Cutaneous leishmaniasis (CL), caused by L. major, L. mexicana, and visceral leishmaniasis caused by L. donovani, is one of the most important neglected tropical diseases. Available treatments are highly toxic, and the serious…
Read MoreTargeting Amyloid Diseases with Self-assembled Cyclic D, L-α-Peptides
The Problem Protein misfolding and aggregation is the fundamental cause of more than 20 amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. These conditions include Alzheimer’s, Parkinson’s, and Huntington’s diseases, and type II diabetes. For Alzheimer’s disease (AD), the oligomerization of amyloid-beta (Aβ) and tau to soluble oligomers and…
Read MoreNovel Personalized Amd and Diabetic Retinopathy Treatment
The Problem Age-Related Macular Degeneration (AMD) and Diabetic Retinopathy (DR) are leading causes of blindness in the Western world. Both are characterized by pathological angiogenesis in the various eye structures. Current treatment for AMD and DR includes monthly intraocular injection of various anti-VEGF agents. Novel biological drug family based on nucleic acid-based ligands, aptamers, is…
Read MoreNovel Drug for Glaucoma Treatment
The Problem Glaucoma is one of the leading causes of blindness in the world. It is a slow and progressive disease that can lead to vision loss over a long period of time. Over 60 million people worldwide lives with glaucoma using multiple therapies in order to prevent blindness- and the patients’ number will grow…
Read MoreNovel Peptides for Treating Cocaine Addiction And Pain
The Problems Drug addiction is a scourge of both developed and less-developed societies. The economic impact of drug addiction includes direct treatment costs as well as lost productivity and crime. Neuropathic pain is a chronic pain condition caused by a primary lesion or dysfunction in the nervous system. It can be a consequence of many different…
Read MoreINNOVATIVE MICRON-SIZE PLASMONIC COLOR SORTER
The Problem Color generation is commonly pigmentation related, and its pixel size is limited to a few and up to tens of microns, two orders of magnitude larger than the diffraction limit in the visible range. Colors can also be generated via interference processes in photonic crystals and in plasmonic sub-wavelength structures. Plasmonic color generators…
Read MoreSurface Engineering & Disaggregation Features of Strong Hardness Chemically Stable Nanodiamonds
The Problem The two major pain points of fully bio-compatible non-toxic carbon-based mechanically hard 4-10 nm-sized nanomaterials (nanodiamonds-NDs) are their high reaction times and their extreme-sized methodologies. These two lead to very difficult surface-functionalizing in a versatile manner for a wide range of full various domains applications. The Solution Our innovation successfully discovered that extremely…
Read MoreNovel 3d Photo-thermal Printing of Metals & Composites
The Problem While 3D printing of polymeric materials is prevalent, metals are indispensable for structural support, heat dissipation, and electrical conductivity. Extensive research to allow additive manufacturing (AM) of metals has resulted in a range of techniques, the most established of them are selective laser melting (SLM), electron beam melting (EBM), and metal inkjet printing.…
Read MorePrevention and Treatment of Viral Infections with Nano-particles Capped with Functional Groups
The Problem Viral infections continuously take place and pose major public health threats; yet, their prevention and treatment modalities are limited while emerging resistant viruses call for the development of alternative treatments. The Solution We developed a novel approach for the prevention and treatment of infections caused by viruses which attach cells via heparan sulfate binding,…
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