Glucose Conjugated Gold Nano-particles for Cancer Detection
Cancer detection is currently based on two insufficient imaging techniques: structural and functional. While structural techniques identify anatomic details and provide information on tumor location, size, and spread, based on endogenous contrast, they are ineffective in detecting critical small tumors or metastases.
The main functional imaging technique, FDG-PET, is based on increased glucose metabolic activity in cancerous tissue. However, it is prone to non-specificity as glucose uptake is not cancer-specific, it is dependent on availability of short-lived cyclotron radiotracers, and above all, it lacks anatomical information of the functional results.
We have developed a novel method that will provide simultaneous functional and structural imaging capabilities, with the most widely available imaging modality – the CT. We have developed Glucose Functionalized Gold Nanoparticles (GF-GNP), which like FDG, detects glucose metabolic activity while inducing distinct contrast in CT imaging. We have discovered that these GF-GNP exhibit increased uptake in cancer cells compared to the surrounding normal tissue.
The Commercial Benefit
Our nanoparticles offer cancer detection and imaging with no dependence on short-lived radiotracers and provides simultaneous anatomical and functional information using CT.
The cancer imaging market is a very large market, according to a recent market report, the global cancer diagnostics market is expected to grow at a CAGR of 7.6% from 2014 to 2020 and reach an estimated value of USD 168.6 billion in 2020. Cancer diagnosis through imaging modalities constitutes the largest portion in the cancer imaging market and is expected to grow at a CAGR of 8.2% from 2014 to 2020.
- Cancer imaging market
- Cancer research laboratories
- Cancer research foundations
- Cancer organizations
Team: Primary Inventor
Prof. Rachela Popovtzer
- Prof. Rachela Popovtzer is a Senior Lecturer in the Faculty of Engineering and a member of the Nano-Medicine Center at the Bar-Ilan Institute of Nanotechnology and Advanced Materials (BINA).
- Prof. Popovtzer is currently the head of the Bioengineering track and the Laboratory for Nano-medicine.
- Prof. Rachela Popovtzer is a winner of numerous international grants and awards, such as the Intel Prize, the EU Environment and Living foundation Prize, and the ATOL Charitable Trust Fellow in NanoMedicine.
Validation in various cancer models and toxicology.
We invite diagnostic companies to license our patent through a licensing agreement with a sponsored research.