Archive for December 2020
Cutting-Edge Complementary Dual Modular Redundancy Memory Cell
The Problem Embedded memories are often operated at scaled supply voltages in order to reduce their power consumption. However, reduction in the supply voltage also increases their susceptibility to soft errors. Soft errors occur when an energetic particle hits a reversed bias junction of an internal node in a memory cell, possibly flipping the data…
Read MoreUltra-Low Power, Nw Level Bandgap Voltage Reference (Bgref)
With advances in the Internet of Things (IoT) applications and the expansion of mobile devices, energy consumption has become a primary focus of attention in integrated circuit design. These mobile battery-operated devices need to operate for extended periods without recharging and therefore requiring ultra-low energy consumption. Many IoT devices require operation in a wide range…
Read MoreCutting-edge, Physical Unclonable Functions Related to Inverter Trip Points
The Problem The huge amount of sensing devices found in future cars, homes, workplaces, and cities require a much stricter security requirement for identification and authentication. It is essential that during hardware communication, the two parties are capable of identifying each other through secret keys and reliable authentication protocols. A technique which has recently emerged…
Read MoreHighly Reliable SRAM PUF
The Problem The huge amount of sensing devices found in future cars, homes, workplaces, and cities require a much stricter security requirement for identification and authentication. However, when the variation is small, the logical value will be determined by noise and can vary from run to run and the bit is unstable. The unstable bits…
Read MoreInnovative Ultra-Miniature Ring Oscillator Temperature Sensor
The Problem An important power management functions in commercial IC’s is temperature sensing. Since commercial processors can have as many as 40 sensors, the industry is constantly pursuing a small, low-power sensor. The Solution We present a promising, novel ultra-miniature ring-oscillator sensor which at 750 um2 is the world’s smallest integrated smart sensor and has the…
Read MoreNovel Coherent Fluorescence Super-Resolution Microscopy
The Problem The localization precision which is limited by the square root of N is obtained due to non-coherent addition of the collected photons. An increase in the precision is required as it leads to significant increase in the imaging resolution for the same amount of illumination of alternatively it allows the same resolution as…
Read MoreUltra-sensitive, Miniature, Low Power, Inexpensive Magnetometer
The Problem Currently, available inexpensive and miniature commercial magnetic sensors exhibit field resolution of hundreds of picotesla and above, while commercial sensors with field resolution of few picotesla and below are normally much larger and more expensive and in some cases operate only at cryogenic temperatures. Namely, there are no commercial magnetic sensors which are…
Read MoreNovel strategy for targeting glycosylated patterns on cancer cells using CAR-cells
The Problem Immunotherapy has become a revolution in the area of cancer treatment. Compared to the traditional methods, such as invasive surgeries, radiation, and chemotherapy, immunotherapy is more specific and less toxic to patients. Chimeric antigen receptor (CAR)-engineered T cell therapy is considered a promising approach since it has shown remarkable ability to eliminate tumors…
Read MoreADAR inhibitors to suppress resistance to immune checkpoint inhibitors
The Problem In recent years, targeted immune therapies are emerging as standard treatments for advanced-stage cancers. These drugs target cell surface checkpoint proteins to stimulate the recognition and destruction of cancer cells by the immune system. Nevertheless, while the immune checkpoint blockade approach can induce durable responses across multiple types of malignancies, these remarkable responses…
Read MoreA Novel Approach for Rational Hepatitis C Virus-Vaccine Design
The Problem HCV is a major public health problem, with over 185 million people infected worldwide and at risk for developing life-threatening liver disease. Although FDA approved several Direct-Acting Antiviral Drugs (DAAs) demonstrating high efficacy and safety, they are highly expensive and unaffordable. Vaccines typically represent the most cost-effective strategy to prevent infectious disease which…
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