256 innovations from Bar-Ilan University, available for licensing, co-investment, or spin-out through BIRAD.
Lindell Yehuda
BIT DECOMPO SITION APPARTUS FOR MAC
Shai Rahimipour
Drug delivery systems play a crucial role in optimizing drug therapy by improving drug efficacy, reducing side effects, enabling targeted delivery, and overcoming biological barriers. They also contribute to advancements in personalized medicine and have the potential to revolutionize healthcare by enhancing treatment outcomes and patient compliance. The advances in genome mapping, molecular diagnosis and production of highly selective humanized antibodies enable the development of precision medicine. Moreover, the emerging technologies in mRNA-based vaccines and treatments together with the breakthrough in gene manipulation using the CRISPR/Cas9 editing methodology have open new avenues in discovery of novel drugs. In general, the translation of these advances into successful therapies relies on the use of biologics, including peptides, proteins and oligonucleotides that exhibit high specificity and potency. However, delivery of drugs and biologics into the brain in different central nervous system conditions, such as Alzheimer’s disease (AD) and Parkinson’s disease, glioblastoma and stroke, remains still a highly challenging endeavor, due to the blood-brain barrier (BBB). Therefore, there is a growing need for small, non-toxic, and affordable molecules that can increase the penetration of biologics and nanoparticles (NPs) carriers through the BBB. In this application, we demonstrate successful delivery of biocompatible liposomes and gold nanoparticles (GNPs) through BBB by systemic (i.p. and i.v.) injection for early diagnosis and therapy of AD. We show that conjugation of non-BBB permeable gold nanoparticles (GNPs) and liposomes with a cell permeable cyclic D,L-a-peptide (CP-2) dramatically increase the BBB permeation of the particles to generate theranostic probes for early diagnosis and therapy of AD. Targeting the oligomeric forms of Aβ in brain, Aβ oligomers and plaques were detected in the well-established 5xFAD mouse model of AD by CT and fluorescent imaging as early as 2-months. In transgenic Caenorhabditis elegans AD models overexpressing human Aβ, CP-2-conjugated NPs significantly outperformed free CP-2 by improving cognitive and behavioral functions, extending lifespan through reducing toxic Aβ oligomer levels.
Albeck Amnon
development of protein-protein interaction inhibitors, whose activity is calcium concentration dependent. Thus, at low calcium conc. the inhibitors will be active (preventing the interaction between the two proteins), but at high concentration they will not interfere with the biological activity.
Salomon Adi
Nanopatterned attachment for nanometric optical standardization
Shor Joseph
This is a disclosure which replaces disclosure # 447 for which a provisional patent has been filed. The Vcc level and temperature of IC’s are important parameters which determine the power / performance. Resonances in the package and platform can cause significant AC voltage droops which can degrade functionality, requiring additional guard-band. Prior-art droop detectors utilize digital delay circuits, such as tunable replica circuits to measure these droops. However, the delay is a strong function of temperature as well as the DC Vcc level, making it difficult to differentiate the AC droop across different voltage and temperature levels. It is proposed to utilize a current controlled oscillator (CCO) with an analog bias to mitigate the voltage and temperature dependencies, such that only the AC droop is measured. The CCO frequency is independent of the DC Vcc level, while the temperature is also characterized along with the AC droop, such that both temperature and droop levels can be extracted.
Ayal Hendel
The invention is cellular based therapies for specifically targeting cells infected with viruses. In particular isolated T-cells and/or TCRs directed against various viruses, methods for their preparation and uses thereof for treating viral infections in subjects.
Zitoun David
All-solid-state sodium batteries offer a promising route toward safe, low-cost, and sustainable energy storage, but their widespread adoption is limited by the lack of solid electrolytes that simultaneously provide high room-temperature ionic conductivity, mechanical flexibility, thin-film processability, and long-term electrochemical stability. Here we introduce a composite solid-state electrolyte based on surfactant-modified sodium-enriched halloysite nanotubes dispersed in polymeric medium. Sodium exchange and surface functionalization transform the naturally abundant clay into an active ion-conducting filler that forms continuous Na⁺ transport pathways while remaining compatible with scalable polymer processing. The resulting self-supporting membranes are as thin as 10 μm, contain up to 50 wt% halloysite while retaining mechanical flexibility, and exhibit a room-temperature ionic conductivity of 3.13 mS cm⁻¹ together with an electrochemical stability window of 4.7 V versus Na/Na⁺. Symmetric Na|Na cells sustain stable cumulative stripping/plating of 500 mAh cm⁻², while Na₃V₂(PO₄)₃|Na cells deliver stable cycling over 5,000 cycles at 20 C with high capacity retention. These results establish naturally abundant halloysite nanotubes as an effective platform for high-performance solid-state sodium electrolytes and demonstrate a scalable strategy for combining fast ion transport, mechanical robustness, and practical battery performance.
Aurbach Doron
Brought herein a novel system for periodic capture and release of CO2 from air using asymmetric configuration electrochemical cells. The capture and release mechanism are based on the "pH swing" principle in which CO2 is efficiently being absorbed into alkaline solution and being released when the solution becomes acidic. Adjustment of the pH of the solution is controlled by passing current through a special asymmetric electrochemical reactor where the solution passes through the reactor. Absorption of CO2 from the air or exhaust gas ("flue gas") is facilitated by passing the solution and CO2 through ordinary absorption column (or tower).
Lior Klein
A method, a non-transitory computer readable medium and a system for compensating for an electromagnetic interference induced deviation of an electron beam. The method may include obtaining measurement information about a magnetic field within an electron beam tool, the measurement information is generated by at least one planar Hall Effect magnetic sensor that is located within the electron beam tool; wherein the at least one planar Hall Effect magnetic sensor comprises at least one magnetometer integrated with at least one magnetic flux concentrator; estimating the electromagnetic interference induced deviation of the electron beam, the estimating is based on the magnetic field; and setting a trajectory of the electron beam to compensate for the electromagnetic interference induced deviation of the electron beam.
Nudelman Abraham
A novel use for the compounds 1-(butyryloxy)ethyl 5-amino-4-oxopentanoate hydrochloride and 1-(butyryloxy)butyl 5-amino-4-oxopentanoate hydrochloride, and their analogs, has been found as agents for the treatment of sickle cell anemia
Klein Shmuel Tomi
The invention relates to a coding system that simultaneously provides both compression and encryption. Systems combining compression and encryption do exist, the innovation here is to devise a single process the output of which is both reduced in space and secure against unauthorized decoding. Contrary to our previous work, in which this was achieved by controlling the coding model by means of a secret key, the present work controls the code generation itself.
Pinkas Binyamin
The invention is about handling data that is shared between several servers such that no server learns the contents of the data. The new invention is a method for verifying that two sets of data are equal. The goal of this comparison is to ensure that none of the servers modified the data. This verification is critical when applying different database operations to the data, in the context of sharing a database of sensitive data between the servers such that none of them learns what’s in the database, and yet the servers are able to run database queries on this shared data.
