80 innovations from Bar-Ilan University, available for licensing, co-investment, or spin-out through BIRAD.
Margel Shlomo
Synthesis and Characterization of Proteinoid and Proteinoid-Polyester Polymers and Nano/Micro-Particles for Industrial and Biomedical Applications
Grinberg Ilya
"מכשירים וחומרים דיאלקטיים של מתנדים בקנה מידה אטומי בתדר רדיו ומיקרוגל
Lellouche Jean-paul
"Effective Nanoscale Delivery System as an anti-Leishmania drug/technological platform for drug delivery"
Nessim Gilbert
The innovation described here consists of synthesizing in a one-step process a self-standing electrode with single-atom catalysts (SACs) supported on a nanocarbon matrix that will outperform the established standards at a much cheaper cost for most electrocatalytic reactions. The scientific breakthrough supporting this research is based on the simultaneous delamination and doping of a thin film stack using chemical vapor deposition (CVD).
Margel Shlomo
A novel, environmentally friendly tactic for precise agricultural pest control utilizing the controlled release of pheromone's and essential oil's volatiles from hollow porous silica microcapsules.
Banin Ehud
This research presents bio-friendly a green and cost-effective antibiofilm coating formulations based on Pickering emulsion templating. The coating does not contain any active material, where its antibiofilm function is based on passive mechanisms, laying solely on the superhydrophobic nature of the coating, and thus highly suitable for food and medical applications. The coating is based on water in toluene or xylene emulsions that are stabilized by commercial hydrophobic silica, with Polydimethylsiloxane (PDMS) that is dissolved in the organic phase. The stability of the emulsions and their structure were studied by confocal microscopy. The most stable emulsions were applied on polypropylene surfaces and dried in an oven to form PDMS/silica rough coatings. The surface morphology of the coatings shows a honeycomb-like structure that exhibits a combination of micron-scale and nano-scale roughness resulting in a superhydrophobic property. The superhydrophobicity of the resulting coatings has been tuned to meet the demands of highly efficient antibiofilm passive activity. The obtained coatings have shown to significantly reduce the accumulation of a decrease of one order of magnitude in the EEscherichia coli-coli accumulation on the surface, suggesting these coatings can be used for antibiofilm applications. that is a significant value for coating with a passive based antibiofilm coating.
NESSIM GILBERT
Osteoarthritis (OA) is a major burden that affects ~ 40 million of EU citizens, with enormous direct and indirect costs for the European healthcare systems, quantified in ~ 50.4 billion euros per year. This disease involves the degeneration of cartilage and other joint structures and is one of the most common causes of pain and disability in middle-aged and elderly people. ADMAIORA aims in the long-term at increasing the healthy and active lifespan of people affected by OA, by considerably slowing down or even stopping the degeneration process, thus delaying or avoiding surgical interventions for total joint replacement. Within the project time-frame the target is to achieve a 60% reduction of degeneration in OA animal models treated with the ADMAIORA technologies, with respect to control (untreated) ones, after 4 weeks, and a 90% reduction after 3 months. To achieve this ambitious objective the Consortium will evolve and merge technologies that already showed a high potential as experimental proof of concepts (TRL = 3) and will bring them at a preclinical level (TRL = 5). The ADMAIORA Consortium will develop biosynthetic hydrogels embedded with carbon-based nanomaterials, conferring higher mechanical and lubrication properties, and piezoelectric nanoparticles enabling responsivity to remote wireless ultrasound waves. Stem cells derived from autologous adipose tissue, which already demonstrated anti-inflammatory and regenerative properties, will be entrapped in the hydrogels. Materials and cells will be delivered in situ through an innovative handheld 3D bioprinter, embedded in an arthroscopic tool. A custom brace will be designed and equipped with ultrasound probes for both monitoring the joint status and stimulating the implanted piezoelectric nanobiomaterial. A dedicated App will allow a direct connection between patient and physician in an Internet of Things framework. Overall, ADMAIORA will target a ground- breaking paradigm that may revolutionize OA treatment.
Zalevsky Zeev
The feasibility analysis for the development and the integration of a Near-field Scanning Optical Microscope (NSOM) tip-photodetector operating in the visible domain of wavelengths to an Atomic Force Microscope (AFM) cantilever has been simulated, processed and measured. The new tip-photodetector consists in a Platinum-Silicon truncated conical photodetector, sharing a subwavelength aperture and processed using advanced nanotechnology tools on a commercial silicon cantilever. Such a combined device enables a dual-mode usage of both AFM and NSOM measurements, when collecting the reflected light, directly from the scanned surface while having a more efficient light collection process. In addition to its quite simple fabrication process, it is demonstrated that the AFM tip, on which the photodetector is processed, is still operational, i.e. the AFM imaging capability is not altered by the process. The AFM-NSOM capability of the processed tip is presented, and obtained results show a significant improvement in surface characterization accuracy and efficiency.
Byk Gerardo
The nanohydrogels (NHGs)are new in away that they are biodegraded slowly after administration. The NHGs can be loaded with drugs such as amphoterycin B or voriconazole for treating fungal infections. The nanohydrogels are monodispersed particles of 100 to 400 nm that have the specialty to be both cross-linked and biodegradable tanks to special cross-linkers used fo their generation. The NHGs are loaded with drugs and display a slow release of the drug both in vitro and in cell assays. The drugs are delivered via intraperitoneal administration and protects the infected animals form lethal doses of fungi strains
Shai Rahimipour
Drug delivery systems play a crucial role in optimizing drug therapy by improving drug efficacy, reducing side effects, enabling targeted delivery, and overcoming biological barriers. They also contribute to advancements in personalized medicine and have the potential to revolutionize healthcare by enhancing treatment outcomes and patient compliance. The advances in genome mapping, molecular diagnosis and production of highly selective humanized antibodies enable the development of precision medicine. Moreover, the emerging technologies in mRNA-based vaccines and treatments together with the breakthrough in gene manipulation using the CRISPR/Cas9 editing methodology have open new avenues in discovery of novel drugs. In general, the translation of these advances into successful therapies relies on the use of biologics, including peptides, proteins and oligonucleotides that exhibit high specificity and potency. However, delivery of drugs and biologics into the brain in different central nervous system conditions, such as Alzheimer’s disease (AD) and Parkinson’s disease, glioblastoma and stroke, remains still a highly challenging endeavor, due to the blood-brain barrier (BBB). Therefore, there is a growing need for small, non-toxic, and affordable molecules that can increase the penetration of biologics and nanoparticles (NPs) carriers through the BBB. In this application, we demonstrate successful delivery of biocompatible liposomes and gold nanoparticles (GNPs) through BBB by systemic (i.p. and i.v.) injection for early diagnosis and therapy of AD. We show that conjugation of non-BBB permeable gold nanoparticles (GNPs) and liposomes with a cell permeable cyclic D,L-a-peptide (CP-2) dramatically increase the BBB permeation of the particles to generate theranostic probes for early diagnosis and therapy of AD. Targeting the oligomeric forms of Aβ in brain, Aβ oligomers and plaques were detected in the well-established 5xFAD mouse model of AD by CT and fluorescent imaging as early as 2-months. In transgenic Caenorhabditis elegans AD models overexpressing human Aβ, CP-2-conjugated NPs significantly outperformed free CP-2 by improving cognitive and behavioral functions, extending lifespan through reducing toxic Aβ oligomer levels.
Salomon Adi
Nanopatterned attachment for nanometric optical standardization
Naveh Doron
Transition Metal Dichalcogenides (TMDCs) are atomically thin semiconductors that are considered as promising platform for future nanoelectronic technologies. The main challenge in realizing such future technologies is the scalable production of high quality wafers of TMDs and the wafer-to-wafer transfer of the TMDCs (from the growth substrate to the target silicon wafer). Most of the R&D effort in TMDCs is focused on MOCVD methods and so far suffering from small crystalline domains and high defect densities. The invention is based on the following steps: 1. preparation of catalytic growth substrate, single (111) domain of gold or platinum on c-plane sapphire 2. ALD deposition of uniform film 2-4 nm MoO3 or WO3 on Au/Pt 111 a. Possible but not required, to anneal MoO3 in O2/plasmaO2/O3 at T>150C 3. React with chalcogen precursor (H2S, S8 vapor, (CH₃)₂S₂ dimethyl disulfide, (C₂H₅S)₂ diethyl disulfide, Se8, H2Se, (CH₃)₂Se₂, Bis(trimethylsilyl)selenide (BTMSe), Di-tert-butyl Selenide (DTBSe), Diethyl Selenide (DESe), (C₂H₅)₂Se, Diethyl Telluride (DETe), (C₂H₅)₂Te, Dimethyl Telluride (DMTe), (CH₃)₂Te, Di-tert-butyl Telluride (DTBTe), Bis(trimethylsilyl)telluride (BTMTe), (TMS)₂Te, and others. a. Reaction of chalcogen with MoO3 can be sequential in pulses as soon as wetting of MoO3 achieved b. Cracking MoO3 in reaction with chalcogen expedited with hydrogen c. Plasma can be applied (Ar,H2) Oriented growth on 111 Au over 4” wafers has been demonstrated at BIU. 8” wafers being demonstrated. For transfer of TMDCs from growth substrate to target silicon: Catalyst tend to form strong vdW forces with TMDCs and after growth it is almost impossible to separate the two. Above 250C, gold interacts with all chalcogen species and reaction expedites with temperature of up to 400C, with Pt the reaction temperatures are somewhat higher than Au. Then, reaction with (for example) oxidizing acid (for example HNO3) can dissolve the chalcogenized catalytic substrate. This leaves a clean layer after transforming the catalyst into a sacrificial layer of the transfer. Figure 1 shows the XRD of Au (111) on sapphire as was sampled on 4” wafer. Figure 2 shows the effect of annealing and reconstruction of strained Au (111). In addition, Figure 3 shows the topographic proof of Au(111) reconstruction as it presents the atomic steps of sapphire on the Au layer. This is a direct proof of epitaxial reconstruction of Au to the substrate. The next step of the process is ALD deposition of MoO3, as evident in Raman spectroscopy of Figure 4. After the reaction with S8 the proof for MoS2: Raman spectroscopy confirm the Ag Eg and 2DLM characteristic modes. In addition, a second harmonic generation measurement proof the crystalline nature with C6 symmetry and global orientation on the wafer area in Figure 5. Figure 1-4 proves that the steps described in the process above were taken and Figure 5 proves that the result is a fully covered MoS2 and with global orientation over 4” wafer.
