256 innovations from Bar-Ilan University, available for licensing, co-investment, or spin-out through BIRAD.
Lindell Yehuda
Full details available on request
Cohen Haim
To explore the role of protein post-translational modifications on lifespan and healthspan , we developed the PHARAOH computational tool based on the 100-fold differences in longevity within the mammalian class. Analyzing acetylome/phosphorylome and proteome data across 107 mammalian species identified 482 and 695 significant longevity-associated acetylated lysine residues in mice and humans, respectively. In addition, we have recognized 2115 longevity associated p phosphorylations. In regards to acetylations, these sites include acetylated lysines in short-lived mammals that were replaced by permanent acetylation or deacetylation mimickers, glutamine or arginine, respectively, in long-lived mammals. Conversely, glutamine or arginine residues in short-lived mammals were replaced by reversibly acetylated lysine in long-lived mammals. For phosphorylations, site these sites include phosphorylated Serine (S), Tyrosine (Y) and threonine (T) or their replacement to aspartic acid (D) or glutamic acid (E)or Alanine (A) and Y to phenylalanine (Y to F). Pathway analyses of the acetylation sites highlighted the involvement of mitochondrial translation, cell cycle, fatty acid oxidation, transsulfuration, DNA repair and others in longevity. A validation assay showed that substitution of lysine 386 with arginine in mouse cystathionine beta synthase, to attain the human sequence, increased the pro-longevity activity of this enzyme. Likewise, replacing the human ubiquitin-specific peptidase 10 acetylated lysine 714 with arginine as in short-lived mammals, reduced its anti-neoplastic function. These findings provide a computational tool for identifying modifications that control longer healthy life and potential interventions to extend human healthspan.
Shuki Wolfus
The invention is an electromagnetic active protection system, designed to neutralize kinetic energy penetrators (such as armor-piercing rods) before they strike a vehicle's main armor. The system consists of an array of charged conductive plates; when a projectile traverses the array, it physically bridges the gap between electrodes, acting as a closing switch to trigger a rapid, high-current electrical pulse. This discharge exploits the "skin effect" to concentrate intense heat specifically at the projectile's tip, softening it significantly, while simultaneously generating an asymmetric Lorentz force that induces a yaw (tilt) angle. The combination of tip softening, shear stresses from differential thermal expansion, and mechanical tumbling causes the projectile to fracture or shatter upon impact, drastically reducing its penetration capability.
Ozana, Nisan
The present invention relates to a non-invasive optical system and method for determining intra-facial connectivity and face–brain connectivity using full-field speckle analysis. The system is configured to illuminate substantially the entire facial surface using coherent or partially coherent light and to capture dynamic speckle patterns generated by facial tissues, including microvascular activity, neuromuscular activity, and micromovements. The captured speckle data are processed to extract temporal and spatial features including, but not limited to, speckle contrast, intensity fluctuations, temporal decorrelation rates, autocorrelation functions, frequency-domain characteristics, phase relationships, and vibration-related parameters. The facial surface is segmented into multiple regions of interest, each generating time-resolved speckle-derived signals. Functional connectivity within the face (intra-facial connectivity) is computed by calculating correlation, coherence, mutual information, phase synchronization, or other statistical or signal-processing metrics between time-series signals derived from different facial regions. These computations generate connectivity matrices and network representations reflecting dynamic coupling patterns across the face. In certain embodiments, brain activity signals are acquired simultaneously or sequentially using electrical, optical, acoustic, or multimodal sensing techniques. The facial speckle-derived signals are synchronized with brain activity measurements to calculate face–brain connectivity using cross-correlation, coherence analysis, causality estimation, or other cross-modal coupling methods. The resulting connectivity maps may reflect functional interactions between facial dynamics and neural activity. The system may further include data processing modules, machine learning algorithms, and classification models configured to identify patterns associated with neurological, psychiatric, or neuromuscular conditions. The invention may be implemented as a stationary, portable, or wearable device and may operate in real time or offline analysis modes. By providing quantitative measurements of intra-facial and face–brain connectivity, the invention enables objective assessment, monitoring, and biomarker development for applications including mental health disorders, addiction, depression, cognitive impairment, neurodegenerative diseases, and facial paralysis of different etiologies.
Yavits Leonid
A dedicated hardware unit embedded within the shared substrate of a heterogeneous multi-chiplet semiconductor package. It continuously monitors the package's physical health using thermal, mechanical strain, and electrical aging sensors, runs embedded AI inference to predict failures, and autonomously adjusts power and frequency to prevent damage and optimize the operation — all from within the package substrate itself.
Cohen Eliahu
Systems and methods are described for quantum information retrieval. An example system may include a quantum cloning unit, a photon number splitting (PNS) unit, and a weak measurement unit to enhance the accuracy and reliability of quantum state estimations without introducing substantial decoherence. The quantum cloning unit may be used to generate approximate clones of a qubit. If the qubit is a multi-photon state qubit, then the photon number splitting (PNS) unit may be used to intercept the multi-photon state qubit and reflect a single photon from the multi-photon state qubit, which may then be subjected to quantum cloning. These qubits and qubit clones may then be subjected to weak measurements, which provides detailed analysis with minimal disturbance to quantum properties such as superposition and entanglement.
Keshet Joseph
There is provided a system for computing a secure statistical classifier, comprising: at least one hardware processor executing a code for: accessing code instructions of an untrained statistical classifier, accessing a training dataset, accessing a plurality of cryptographic keys, creating a plurality of instances of the untrained statistical classifier, creating a plurality of trained sub-classifiers by training each of the plurality of instances of the untrained statistical classifier by iteratively adjusting adjustable classification parameters of the respective instance of the untrained statistical classifier according to a portion of the training data serving as input and a corresponding ground truth label, and at least one unique cryptographic key of the plurality of cryptographic keys, wherein the adjustable classification parameters of each trained sub-classifier have unique values computed according to corresponding at least one unique cryptographic key, and providing the statistical classifier, wherein the statistical classifier includes the plurality of trained sub-classifiers.
Shwartz Sharon
The invention enables new x-ray imaging methods that provide not just the shape of the image but also the atomic species it is composed of. In addition, the apparatus based our approach requires lower dose than conventional x-ray imaging and improve the visibility and the signal-to-noise of the image leading to images that are clearer than in conventional x-ray imaging systems.
Barda-saad Mira
This patent claims the usage of a small-molecule compound, SMC #13, to control and mitigate chronic inflammation
Okun Eitan
Down Syndrome (DS), which results from a trisomy of chromosome 21 (Hsa21), is the most prevalent genetic cause of intellectual disability worldwide1-3. Some genes on the human chromosome 21 are highly correlated to Alzheimer's disease (AD) pathogenesis, including the amyloid precursor protein (APP), which is overexpressed in individuals with DS, causing early-onset AD (EOAD)-related neuropathology4-6. Furthermore, an alarming association was found between pregnancy with a DS-affected fetus and a 5-fold increased risk of mothers developing late-onset AD (LOAD) later in life, compared with pregnancies with fetuses affected by other forms of intellectual disability7,8. We suggest that fetomaternal transfer of APP and its proteolytic fragments occurs during pregnancy with a DS fetus and that these fetal factors infiltrate the maternal central nervous system, contributing to Aβ-seeding in the maternal brain, adversely affecting their cognitive abilities. By modeling DS-like pregnancies in mice, by mating of wild-type (WT) female mice for 4 consecutive pregnancies with mouse strains that overexpress the human amyloid precursor protein (hAPP) during early embryonic stages, we have observed fetal DNA, mRNA, proteins, and cells in the mothers' brains and periphery tissues following pregnancies, resulting in maternal cognitive decline. To delay the observed cognitive decline resulting from the transfer of neurotoxic peptides, we have generated a novel vaccine specific for the human neurotoxic N-terminal epitope of APP, the N-APP (APP108-113) fragment, which we observed to reside in the periphery of Aβ plaques in the brain of EOAD mouse brains and present in the brains of mothers to hAPP-expressing mouse fetuses. Vaccinating WT female mice with the N-APP vaccination prior to their exposure to hAPP-expressing fetuses improved short-term memory abilities in several behavioral assays and may therefore be helpful as a preventative treatment for maternal cognitive decline following DS pregnancies. In addition, vaccinating 5xFAD mice, which model EOAD, with the N-APP vaccine, improved cognitive measures in various cognitive tasks.
Lewi Tomer
The invention includes a tiny optical element in the form of two or three dimensional arrays, that retains its expected performance over a large range of temperatures. As opposed to any other optical element in which the optical properties always vary with the temperature, the current invention engineers each unit cell in the array from two or more materials with opposite thermo-optic coefficients, in order to construct a device with no temperature dependence. Hence, these types of temperature invariant metasurfaces- can operator exactly the same even if the temperature changes dramatically
Levy Oren
We introduce a unique and novel customizable 3D interface for producing scalable, biomimetic artificial reefs (ARs), utilizing real data collected from coral ecosystems. This interface employs 3D technologies, 3D imaging with AI generative models, and 3D printing, to extract core reef characteristics, which can be translated and digitized into a 3D printed reef. The advantages of 3D printing lie in providing customized tools by which to integrate the vital details of natural reefs, such as rugosity and complexity, into a sustainable manufacturing process. This methodology can offer economic solutions for developing both small and large-scale biomimetic structures for a variety of restoration situations, that closely resemble the coral reefs they intend to support. Our method consists of the following steps: 1. 3D photogrammetric scan. 2. Generating 3D models based on the scans and prior knowledge from reefs. 3. Printing the generated 3D models. Artificial reefs are designed to resemble natural reefs to the highest degree possible, maximizing restoration efforts both ecologically and aesthetically. Coral reefs are mapped in 3D by diver-based or platform passed using AUV photogrammetry. This technology enables the production of highly detailed 3D models of the substrate and detection of the sessile organisms that inhabit the reef. Conducting photogrammetric surveys in areas which are designated for reef reformation with our ARs, is highly beneficial, as it identifies which natural reef structures harbor the large biodiversity as well as depicting their numerical composition (diversity) within the reef structure using unique AI. CAD design platforms (i.e., Rhinoceros© and Grasshopper©) create biomimetic or bio-inspired designs, using ceramic 3D printing (3DP). Incorporating our 3D model (images) provides a natural foundation to interactively customize it to fit the needs of any type of reef geographically, depth, etc. or refine the biomimetic design. The 3D models are further analyzed geometrically using advanced data-analysis tools, to extract the general features and characteristics that will lead to a successful AR. We offer plug-ins for designing artificial structures that consolidate algorithms based on the formation of a coral reef structure and our eDNA information that can predict the types of biodiversity it may maintain/accommodate. An eDNA and metabarcoding package is combined to monitor and extract key biological and ecological information about coral reefs, indicating its pivotal potential as an evaluation tool for ARs and reef restoration success. Removable appendages incorporated in the desing of our ARs, will be used for eDNA biomass (organism) surveys, alongside seawater samples, without interfering with the restoration process. As the information extracted from eDNA is broadly expansive, it can be utilized to predict biodiversity outcomes of the 3D printed AR based on the 3D imaged reef. Furthermore, eDNA data can help to understand what characteristics of the 3D modeled reef are related to the diversity of organisms that inhabit it, which guide further the fabrication of the AR. eDNA is a useful tool to observe these hard to identify communities and to understand which species benefit most from the AR structure. This information will be collected to understand the community composition, abundance, and richness, available through eDNA analysis. Data collected from coral reefs, using eDNA and 3D imaging, can reinforce their resilience through establishing baselines, monitoring, and evaluation of restoration activities. Combining these data-acquisition tools with 3DP offers a holistic approach to manufacturing biomimetic ARs that are tailor-made to any coral reef worldwide. Eventually leading to an entirely data-driven interface utilizing parametric design software and machine-learning tools to curate an algorithm for customizing ARs, according to the specific, desired characteristics of the reef, such as reef structure/type, biodiversity, depth, coral morphology, etc. Moreover, the algorithm will automate the optimization of AR designs according to the data it is supplied from eDNA, 3D imaging, and other monitoring surveys. This methodology would make it possible to determine the precise design parameters needed to construct an AR, provide a baseline for the expected biodiversity that could accumulate on 3D printed ARs, and ensure no excess waste in the manufacturing process. The development of sustainable large-scale and long-term projects that can provide key social and economic benefits will be a demand of the future. When marine restoration projects manage to meet these requirements, they are able to achieve restoration goals together with social and economic change. Novelty Point out the novel aspects, of your invention (what is new about it, or what are its new features) in detail. Please emphasize the non-obvious/unpredicted aspects of the invention. The novelty of this invention lies in the fabric of the following ingredients: 1. Using unique and novel AI algorithm to map the local biodiversity to select “hotspot” biomimicry reefs. 2. Using novel generative AI methods to generate 3D models based on 3D photogrammetric scans of the environment. 3. Using a unique and novel cross-examination of the AI analyzing with eDNA – predictive biodiversity of 3D printed reef 4. Using unique and novel translation of 3D photogrammetric scanning of the reef into a 3D printable shape. 5. Using unique and novel algorithm to translate the 3D shape into a movement of the 3D printing of pasty materials, such as clay, aligned with calcium carbonate 4f. Advantages of the Invention Describe the advantages of your invention over the conventional manner for solving the problem, describing how and why your invention does it better: The advantages of the invention are: 1. Biomimicry/natural reef replication 2. High rate of biological success 3. Eco-materials using clay 4. Tailor made for any location. 5. Cost effective with digital manufacturing 6. Integration of a process by using multi-disciplinary approach: 7. Incorporation of reef and environmental characteristics 8. Large-scale solutions using advanced scaling and fabrication
