256 innovations from Bar-Ilan University, available for licensing, co-investment, or spin-out through BIRAD.
Stern Michael
Full details available on request
Shpaisman Hagay
A device used for manipulation of intraocular particles within the anterior and posterior chambers of the eye by applying directional acoustic energy in specific patterns. The particles can be either moved to or from a desired location and can be reconfigured to predetermined shapes based on acoustic parameters.
Cohen Nava
Full details available on request
Naveh Doron
Leveraging a single, widely tunable photodetection element, we propose to realize an on-chip spectrometer covering the mid-infrared (mid-IR) wavelength range from 2 to 8 um. This invention will demonstrate the feasibility of realizing on-chip spectroscopy based on a single, microscale device. This demonstration will also lay the foundation for the future realization of chip-scale spectral imaging in the mid-infrared wavelength range.
Desiatov Boris
he invention relates to a hybrid optical phased array (OPA) platform combining thin-film lithium niobate (TFLN) photonic circuits with three-dimensional polymer end-fire antennas fabricated using two-photon polymerization. The architecture enables compact, broadband, and high-speed optical beam steering by integrating electro-optic phase control with elevated 3D antenna arrays. The technology is suitable for applications including LiDAR, free-space optical communication, and adaptive photonic systems.
Aurbach Doron
We intend to prepare and optimize anodes in rechargeable aqueous Na ions batteries for large & safe energy storage. The invention includes selection of appropriate redox polymers add to it carbon nanotubes, thus preparing stand-alone composite electrodes. We will select also appropriate electrolyte solutions, and will optimize parameters in prototype Na ion cells.
Cohen Yigal
We discovered a new gene in basil Pb2 which controls resistance against downy mildew.
Meital Gal Tanamy
Hepatitis C virus (HCV) is a major public health concern, with about 60 million people infected worldwide, who are at risk for developing life-threatening liver disease. No vaccine is available, and immunity against the virus is not well understood. HCV usually causes chronic infections. However, 20-40% of infected individuals experience spontaneous recovery, suggested to be mediated by HCV-specific immunity. Therefore, comparing immune responses between spontaneous clearer (SC) and chronically infected (CI) individuals may identify mechanisms governing successful viral clearance and lead to designing effective vaccines. It is now widely accepted that broad neutralizing antibodies that cross neutralize heterogeneous viral isolates play a key role in HCV clearance. However, since most of the HCV-neutralizing antibodies developed and characterized to date were isolated from CIs, the nature and epitope specificities of nAbs in SC HCV infections are not well understood. We recently revealed novel distinct epitopes that are associated with infection clearance. To identify the linear immunodominant epitopes associated with viral clearance, we employed an unbiased approach. We screened a phage-display library presenting random peptides to detect binders to antibodies in serum samples from SC and CI HCV infections. This methodology enabled us to capture a comprehensive view of the various immunodominant epitopes in each patient group and compare between them. We identified three SC-unique epitopes that were synthetically synthesized as peptides and validated that these are immunodominant neutralization epitopes specifically in SCs. Importantly, we showed that these epitopes may be efficiently represented by linear peptides, an important observation considering that most of the HCV neutralization epitopes are conformational. by in vivo experiments were we immunized mice with these peptides, we validated their ability to elicit an anti-HCV antibody-mediated immune response. Importantly, we showed that SC-unique epitopes induced a broader and stronger neutralization response compared to other known epitopes. The mixed-peptides sera exhibited the highest neutralization capacity across almost all HCV genotypes. Therefore, this rational design of anti-HCV peptide vaccine induces a broad and efficient antibody immune response.
Shamay Meir
Kaposi’s sarcoma-associated herpesvirus (KSHV, HHV-8) is associated with several human malignancies. Primary effusion lymphoma (PEL) is an aggressive B-cell lymphoma that is universally associated with KSHV. The lack of optimized therapy combined with the aggressive nature of PEL results in a short median survival of only 6 months. We have found that the interaction between the viral protein LANA and the cellular protein MeCP2 is essential to maintain viral latency. We designed a peptide that disrupts this interaction. We confirmed that the peptide disrupts the recruitment of LANA by MeCP2. Treatment of PEL cells with the peptide inhibited cell proliferation. We propose this peptide as a treatment for KSHV-associated malignancies, such as PEL.
Gelbard Roy
Full details available on request
Noked Malachi
Zinc–bromine batteries (ZBBs) are promising candidates for large-scale energy storage due to their low cost, inherent safety, and high theoretical energy density. However, conventional flow-based ZBBs suffer from low system-level energy density and operational complexity. Recent interest has shifted toward flowless ZBBs (FL-ZBBs) configuration, yet these face critical challenges associated with uncontrolled diffusion and self-discharge (SD) of bromine species at the cathode. One of the holy grails in addressing these challenges is the use of quaternary ammonium salts (NR₄⁺), which interact with bromine species to inhibit their diffusion. In this work, through a targeted localized presence (TLP) approach, wherein bromine-complexing agents (BCAs) are impregnated directly into porous carbon cathodes, we demonstrate that phosphonium-based BCAs, particularly tetrabutylphosphonium bromide (TBP), outperform traditional ammonium-based analogs in FL-ZBBs. TBP enables high Coulombic efficiency (>98.5%, 1 A g⁻¹) for 145 mAh g⁻¹, reduces the SD phenomenon, and achieves long-term cycling stability of over 500 cycles with >97% CE (1.5 A g⁻¹, 145 mAh g⁻¹), even under low electrolyte concentrations (0.5M ZnBr2). The enhanced performance is attributed to faster 2Br⁻/Br₂ redox kinetics, as demonstrated by cyclic voltammetry, and improved molecular polybromide∙∙∙PR₄⁺ interactions, highlighting phosphonium salts as more attractive BCA compounds for high-performance FL-ZBBs.
Naveh Doron
A computational spectrometer system based on a voltage-tunable GeSe-InSe heterojunction device that addresses nonlinear photoresponses through piecewise linearization using classification and hierarchical clustering models for accurate spectral reconstruction.
