80 innovations from Bar-Ilan University, available for licensing, co-investment, or spin-out through BIRAD.
Lewi Tomer
The invention includes a tiny optical element in the form of two or three dimensional arrays, that retains its expected performance over a large range of temperatures. As opposed to any other optical element in which the optical properties always vary with the temperature, the current invention engineers each unit cell in the array from two or more materials with opposite thermo-optic coefficients, in order to construct a device with no temperature dependence. Hence, these types of temperature invariant metasurfaces- can operator exactly the same even if the temperature changes dramatically
Levy Oren
We introduce a unique and novel customizable 3D interface for producing scalable, biomimetic artificial reefs (ARs), utilizing real data collected from coral ecosystems. This interface employs 3D technologies, 3D imaging with AI generative models, and 3D printing, to extract core reef characteristics, which can be translated and digitized into a 3D printed reef. The advantages of 3D printing lie in providing customized tools by which to integrate the vital details of natural reefs, such as rugosity and complexity, into a sustainable manufacturing process. This methodology can offer economic solutions for developing both small and large-scale biomimetic structures for a variety of restoration situations, that closely resemble the coral reefs they intend to support. Our method consists of the following steps: 1. 3D photogrammetric scan. 2. Generating 3D models based on the scans and prior knowledge from reefs. 3. Printing the generated 3D models. Artificial reefs are designed to resemble natural reefs to the highest degree possible, maximizing restoration efforts both ecologically and aesthetically. Coral reefs are mapped in 3D by diver-based or platform passed using AUV photogrammetry. This technology enables the production of highly detailed 3D models of the substrate and detection of the sessile organisms that inhabit the reef. Conducting photogrammetric surveys in areas which are designated for reef reformation with our ARs, is highly beneficial, as it identifies which natural reef structures harbor the large biodiversity as well as depicting their numerical composition (diversity) within the reef structure using unique AI. CAD design platforms (i.e., Rhinoceros© and Grasshopper©) create biomimetic or bio-inspired designs, using ceramic 3D printing (3DP). Incorporating our 3D model (images) provides a natural foundation to interactively customize it to fit the needs of any type of reef geographically, depth, etc. or refine the biomimetic design. The 3D models are further analyzed geometrically using advanced data-analysis tools, to extract the general features and characteristics that will lead to a successful AR. We offer plug-ins for designing artificial structures that consolidate algorithms based on the formation of a coral reef structure and our eDNA information that can predict the types of biodiversity it may maintain/accommodate. An eDNA and metabarcoding package is combined to monitor and extract key biological and ecological information about coral reefs, indicating its pivotal potential as an evaluation tool for ARs and reef restoration success. Removable appendages incorporated in the desing of our ARs, will be used for eDNA biomass (organism) surveys, alongside seawater samples, without interfering with the restoration process. As the information extracted from eDNA is broadly expansive, it can be utilized to predict biodiversity outcomes of the 3D printed AR based on the 3D imaged reef. Furthermore, eDNA data can help to understand what characteristics of the 3D modeled reef are related to the diversity of organisms that inhabit it, which guide further the fabrication of the AR. eDNA is a useful tool to observe these hard to identify communities and to understand which species benefit most from the AR structure. This information will be collected to understand the community composition, abundance, and richness, available through eDNA analysis. Data collected from coral reefs, using eDNA and 3D imaging, can reinforce their resilience through establishing baselines, monitoring, and evaluation of restoration activities. Combining these data-acquisition tools with 3DP offers a holistic approach to manufacturing biomimetic ARs that are tailor-made to any coral reef worldwide. Eventually leading to an entirely data-driven interface utilizing parametric design software and machine-learning tools to curate an algorithm for customizing ARs, according to the specific, desired characteristics of the reef, such as reef structure/type, biodiversity, depth, coral morphology, etc. Moreover, the algorithm will automate the optimization of AR designs according to the data it is supplied from eDNA, 3D imaging, and other monitoring surveys. This methodology would make it possible to determine the precise design parameters needed to construct an AR, provide a baseline for the expected biodiversity that could accumulate on 3D printed ARs, and ensure no excess waste in the manufacturing process. The development of sustainable large-scale and long-term projects that can provide key social and economic benefits will be a demand of the future. When marine restoration projects manage to meet these requirements, they are able to achieve restoration goals together with social and economic change. Novelty Point out the novel aspects, of your invention (what is new about it, or what are its new features) in detail. Please emphasize the non-obvious/unpredicted aspects of the invention. The novelty of this invention lies in the fabric of the following ingredients: 1. Using unique and novel AI algorithm to map the local biodiversity to select “hotspot” biomimicry reefs. 2. Using novel generative AI methods to generate 3D models based on 3D photogrammetric scans of the environment. 3. Using a unique and novel cross-examination of the AI analyzing with eDNA – predictive biodiversity of 3D printed reef 4. Using unique and novel translation of 3D photogrammetric scanning of the reef into a 3D printable shape. 5. Using unique and novel algorithm to translate the 3D shape into a movement of the 3D printing of pasty materials, such as clay, aligned with calcium carbonate 4f. Advantages of the Invention Describe the advantages of your invention over the conventional manner for solving the problem, describing how and why your invention does it better: The advantages of the invention are: 1. Biomimicry/natural reef replication 2. High rate of biological success 3. Eco-materials using clay 4. Tailor made for any location. 5. Cost effective with digital manufacturing 6. Integration of a process by using multi-disciplinary approach: 7. Incorporation of reef and environmental characteristics 8. Large-scale solutions using advanced scaling and fabrication
Popovtzer Rachala
We have recently developed a new imaging technology, which is similar to FDG-PET, yet is cancer specific, and provides the ability to distinguish between cancer and metabolically active inflammatory processes. This novel technology utilizes glucose-functionalized gold nanoparticles (GF-GNP) as metabolically-targeted CT contrast agents. It sensitively discriminates between tumors and inflammation due to the unique biodistribution and pharmacokinetic profile of nanoparticles, and due to dissimilarities in angiogenesis occurring under the different pathologic conditions. Unfortunately, gold nanoparticles are far from being used in clinical trials due to the high risk of accumulation and long-term toxicity. For this reason, an advanced nanocarrier for immediate clinical use must be developed. In the present project, we propose to develop nanocarriers which will be composed of FDA-approved, biodegradable polymeric materials, coated with glucose. By modifying the surface of these nanocarrie
Shai Rahimipour
There is still an urgent need for effective and accessible treatments for Alzheimer’s disease (AD). Soluble Aβ oligomers have been identified as the most neurotoxic species in AD and tested as potential targets for antibody-based drug development to prevent cognitive decline in patients. However, controversy exists concerning their efficacy and safety. We propose an alternative approach to inhibit the formation of the most neurotoxic Aβ oligomers through the targeted oxidation of specific amino acids to prevent the aggregation and toxicity of Aβ. The selective oxidation is obtained by exploiting reactive singlet oxygen locally produced by the interaction of biocompatible and blood brain barrier permeable multicomponent nanoscintillators with X-rays. We demonstrate that surface-modified nanoscintillators interact selectively with Aβ and upon irradiation with X-ray inhibit the formation of neurotoxic Aβ aggregates both in vitro and in vivo. Feeding transgenic Caenorhabditis elegans expressing human Aβ with the surface-modified nanoscintillators and soft X-ray irradiation reduced Aβ oligomer levels, prolonged lifespan and recovered memory and behavioral deficits, thus warrant further development of X-ray based therapy of AD to reach the clinical trial stage.
Elbaz Alon Lior
We developed a new family of catalysts and supports for electrolyzers, based on aerogel chemistry. Transition metals such as Ni, Fe, Co, Ti, Cu, and others have been used to synthesized single, double and triple metal oxides in high surface area morphology called aerogel. This allows high catalyst utilization and synergistic effect between the metal to achieve significantly better performance in electrolyzers to produce green hydrogen.
Salomon Adi
We have developed a facile way for fabrication of transparent fluorescent thin films with different colors. The emission is efficient and by using 488 nm laser beam 3 different emission layers can be excited (530 nm, 570 nm and 620 nm). Thus, we one can get a green, yellow, orange and white emission (combination of 2 colors) from those transparent layers. The films are very homogenous (no crystals etc.) and we can cover large areas of tens of centimeters. Our development is based on hydrogel nanoparticles (HNPs) to which different type of emitters have been chemically attached so to have liquid dye solutions which can be easily deposited on surfaces. Following this technique aggregation of the dye molecules is prevented resulted as stable high quantum yield emitters.
Lior Klein
Under some condictions it is possible to induce and control the magnitude and orientation of pependicular magnetization at the interface of a heavy metal and a ferromagnet by changing the orientation of the in-plane magnetization in the ferromagnetic fi lm. We have indications that it happend due to Dzyaloshinskii–Moriya interaction (DMI) which can be controlled with strain engineering.
Margel Shlomo
The present invention relates generally to the field of compositions comprising one or more silane-based compound or silica coatings and is directed to methods of using the same such as for ultra-violet light absorbing coatings or anti-fogging and superhydrophobic coatings.
Noked Malachi
This new form is submitted to replace Tagliot no. 108, that was already approved, since there is a need to add an Inventor Limited stability of most electrode materials (EM) under stringent operating conditions is a matter of concern for the battery research community and industry. In past few years, it has been demonstrated that EMs degrade through their reactive interface with the electrolyte. Undesirable interfacial reactions result in formation of solid precipitates that impede the charge transfer, and can serve as an active site for electrolyte consumption, anode corrosion and passivation, thereby, leading to inefficient lithium/sodium ion batteries (LIB/SIB). Especially, the progress of high energy and high voltage batteries is mostly restricted by issues associated with the electrode/electrolyte interfacial instability and electro-chemomechanical degradation under the operation conditions7–9. Consequently, stabilizing the interface by creating a protection layer commonly known as “artificial solid electrolyte interphase (ASEI)” can significantly enhance battery performance by stabilizing the functional interface and avoiding the undesirable parasitic reactions between electrode and electrolyte. Significance of this invention resides in bringing a new class of metalloid based protection layers with a diverse range of tailor made options into the field of electrochemical energy storage. This is a completely new thin films composition to explore for the battery community. The proposed silicon based compounds can also be extended to the field of solid state electrolyte with the benefit of metal enrichment and optimized ionic conductivity. Additionally, the special compound used as precursor herein, enables the synthesis of thin complex layer using a single source compound
Klein Lior
Multi-state magnetic memory element
Popovtzer Rachala
The next generation FDG-PET, based on radioactive
Gedanken Aharon
Imparting super hydrophobic properties to substrares by the Sonochemical method
