62 innovations from Bar-Ilan University, available for licensing, co-investment, or spin-out through BIRAD.
Shai Rahimipour
There is still an urgent need for effective and accessible treatments for Alzheimer’s disease (AD). Soluble Aβ oligomers have been identified as the most neurotoxic species in AD and tested as potential targets for antibody-based drug development to prevent cognitive decline in patients. However, controversy exists concerning their efficacy and safety. We propose an alternative approach to inhibit the formation of the most neurotoxic Aβ oligomers through the targeted oxidation of specific amino acids to prevent the aggregation and toxicity of Aβ. The selective oxidation is obtained by exploiting reactive singlet oxygen locally produced by the interaction of biocompatible and blood brain barrier permeable multicomponent nanoscintillators with X-rays. We demonstrate that surface-modified nanoscintillators interact selectively with Aβ and upon irradiation with X-ray inhibit the formation of neurotoxic Aβ aggregates both in vitro and in vivo. Feeding transgenic Caenorhabditis elegans expressing human Aβ with the surface-modified nanoscintillators and soft X-ray irradiation reduced Aβ oligomer levels, prolonged lifespan and recovered memory and behavioral deficits, thus warrant further development of X-ray based therapy of AD to reach the clinical trial stage.
Salomon Adi
We have developed a facile way for fabrication of transparent fluorescent thin films with different colors. The emission is efficient and by using 488 nm laser beam 3 different emission layers can be excited (530 nm, 570 nm and 620 nm). Thus, we one can get a green, yellow, orange and white emission (combination of 2 colors) from those transparent layers. The films are very homogenous (no crystals etc.) and we can cover large areas of tens of centimeters. Our development is based on hydrogel nanoparticles (HNPs) to which different type of emitters have been chemically attached so to have liquid dye solutions which can be easily deposited on surfaces. Following this technique aggregation of the dye molecules is prevented resulted as stable high quantum yield emitters.
Popovtzer Rachala
The next generation FDG-PET, based on radioactive
Fixler Dror
Light-tissue interaction is common in clinical treatments and medical researches, therefore the investigation of light path in irradiated tissue is of high importance. The innovation of this application rises from the combination of two different research areas: theoretical models of light path in irradiated tissues (Diffusion Reflection- DR) and the optical properties of gold nanoparticles. These theoretical models, which were developed about twenty years ago, suggested different reflection profiles for different tissue structures. Still, a diagnostic tool for cancer detection, based on these theoretical models, was still not developed. The use of gold nanoparticles as absorption contrast agents introduces the DR measurements of tumors as a highly sensitive, simple method for cancer detection purposes
Keshet Joseph
Predicting glottal closure insufficiency using fundamental frequency contour analysis
Shor Joseph
Ultra-Miniature Ring-Oscillator Thermal Sensor
Shor Joseph
Miniaturized Thermistor Based Thermal Sensor
Zalevsky Zeev
Remote sensing of vital signs using microwaves
Shefi Orit
Organized magnetic micro and nano particles in gels as a scaffold for promoting and directing cellular growth
Mandel Yossi
Carbon nanoparticles aptasensor for sensing and treatment of retinal neovascularization in AMD and diabetic retinopathy
Popovtzer Rachala
Sugar bait-molecule for preferential gold nanoparticle uptake: development of a novel metabolic based methodology for functional CT imaging
Ruthstein Sharon
64Cu based radiotracer for hypoxia induction for PET/SPECT imaging
