62 innovations from Bar-Ilan University, available for licensing, co-investment, or spin-out through BIRAD.
Polat Uri
When there is a deviation between radii of curvature of the cornea or lens a blurred image is obtained on the retina, this phenomenon is known as astigmatism. Traditional vision exams aiming to find the strength and angle of the astigmatism are performed in clinics by an optometrist or ophthalmologist and require full spheric correction of the participant. There are several exams to diagnose the astigmatism (The clock test, Jackson Crossed cylinder, etc.); All these are exams performed from a distance of 20 feet (6 meters). Our innovation: The Radar Test of Astigmatism (RTA) Is an innovative exam for finding the angle and the power of the astigmatism. The advantages of the new method are: 1. It can be performed even when the subject is not optically corrected at all. 2. The test is performed on a computer screen from a short distance (1 meter). 3. The test is easy to operate and is performed independently by the subject himself. 4. The test is very fast. we found a strong correlation between computerized and clinical data (R² = 0.9892).
Shai Rahimipour
There is still an urgent need for effective and accessible treatments for Alzheimer’s disease (AD). Soluble Aβ oligomers have been identified as the most neurotoxic species in AD and tested as potential targets for antibody-based drug development to prevent cognitive decline in patients. However, controversy exists concerning their efficacy and safety. We propose an alternative approach to inhibit the formation of the most neurotoxic Aβ oligomers through the targeted oxidation of specific amino acids to prevent the aggregation and toxicity of Aβ. The selective oxidation is obtained by exploiting reactive singlet oxygen locally produced by the interaction of biocompatible and blood brain barrier permeable multicomponent nanoscintillators with X-rays. We demonstrate that surface-modified nanoscintillators interact selectively with Aβ and upon irradiation with X-ray inhibit the formation of neurotoxic Aβ aggregates both in vitro and in vivo. Feeding transgenic Caenorhabditis elegans expressing human Aβ with the surface-modified nanoscintillators and soft X-ray irradiation reduced Aβ oligomer levels, prolonged lifespan and recovered memory and behavioral deficits, thus warrant further development of X-ray based therapy of AD to reach the clinical trial stage.
Popovtzer Rachala
The next generation FDG-PET, based on radioactive
Fixler Dror
Light-tissue interaction is common in clinical treatments and medical researches, therefore the investigation of light path in irradiated tissue is of high importance. The innovation of this application rises from the combination of two different research areas: theoretical models of light path in irradiated tissues (Diffusion Reflection- DR) and the optical properties of gold nanoparticles. These theoretical models, which were developed about twenty years ago, suggested different reflection profiles for different tissue structures. Still, a diagnostic tool for cancer detection, based on these theoretical models, was still not developed. The use of gold nanoparticles as absorption contrast agents introduces the DR measurements of tumors as a highly sensitive, simple method for cancer detection purposes
Keshet Joseph
Predicting glottal closure insufficiency using fundamental frequency contour analysis
Shor Joseph
Ultra-Miniature Ring-Oscillator Thermal Sensor
Shor Joseph
Miniaturized Thermistor Based Thermal Sensor
Zalevsky Zeev
Remote sensing of vital signs using microwaves
Shefi Orit
Organized magnetic micro and nano particles in gels as a scaffold for promoting and directing cellular growth
Mandel Yossi
Carbon nanoparticles aptasensor for sensing and treatment of retinal neovascularization in AMD and diabetic retinopathy
Popovtzer Rachala
Sugar bait-molecule for preferential gold nanoparticle uptake: development of a novel metabolic based methodology for functional CT imaging
Ruthstein Sharon
64Cu based radiotracer for hypoxia induction for PET/SPECT imaging
