toxic oligomers

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Targeting Amyloid Diseases with Self-assembled Cyclic D, L-α-Peptides

By Assaf Sagiv / December 17, 2020 / Comments Off on Targeting Amyloid Diseases with Self-assembled Cyclic D, L-α-Peptides

Protein misfolding and aggregation is the fundamental cause of more than 20 amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. These conditions include Alzheimer’s, Parkinson’s, and Huntington’s diseases, and type II diabetes. For Alzheimer’s disease (AD), the oligomerization of amyloid-beta (Aβ) and tau to soluble oligomers and their accumulation…

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